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Anti-BCMA Recombinant Antibody Products

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Anti-BCMA Recombinant Antibody Products

  • BAFF-PE immunotoxin (AGTO-L075E)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • BAFF-DT immunotoxin (AGTO-L075D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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For Research Use Only. Not For Clinical Use.


Creative Biolabs specializes in a wide array of BCMA recombinant antibodies, backed by extensive technical assistance to enhance experimental performance. Our experienced scientists are available around the clock to address any inquiries regarding BCMA recombinant antibodies, guaranteeing their efficacy and reliability for your research needs. Furthermore, we provide validation data and suggested protocols, empowering researchers to achieve consistent and dependable results with our antibodies.

BCMA: A Powerful and Pivotal Target for Tumors

B-cell maturation antigen (BCMA) (also named TNFRSF17) plays a crucial role in the survival and differentiation of B cells and plasma cells. Its increased expression is linked to the advancement of multiple myeloma (MM) and is indicative of a worse clinical outcome. Immunotherapies targeting BCMA have demonstrated significant efficacy and safety in MM patients who have undergone multiple lines of treatment. Therefore, the development of BCMA-specific antibodies provides a promising approach to harnessing the immune system to target and eliminate cancer cells.

Alternative Names

BCM; B-cell maturation factor; B-cell maturation antigen; B-cell maturation protein; Tumor necrosis factor receptor superfamily member 17; TNFRSF17; CD269; TNFRSF13A.

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Anti-BCMA rAb Products

Our high-quality BCMA recombinant antibodies are designed for precise targeting of the BCMA protein. Tailored through advanced engineering techniques, these antibodies exhibit enhanced efficacy and specificity, providing essential tools for researchers investigating the implications of BCMA in oncogenesis and the exploration of innovative cancer treatments. Meanwhile, we offer a diverse selection of BCMA recombinant antibodies with various formulations and conjugations, catering to a wide array of experimental requirements.

Table 1. Featured anti-BCMA recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
PABL-019 Recombinant Mouse Anti-BCMA Antibody (J22.9-xi) Human Mouse IgG ELISA, FC, Neut, FuncS

Creative Quality Control

At Creative Biolabs, our BCMA recombinant antibodies are meticulously developed through a robust quality assurance framework, guaranteeing unparalleled product integrity. This comprehensive approach allows us to deliver dependable and potent BCMA recombinant antibodies tailored to meet the demands of researchers and healthcare professionals engaged in cutting-edge immunotherapy and oncology research.

Customer Reviews

Excellent
Be***ov**h
Rabbit Anti-BCMA Recombinant Antibody (VS-0723-WK197) (CAT#: VS-0723-WK197)
I recently used the Rabbit Anti-BCMA Recombinant Antibody in my flow cytometry experiments, and I couldn't be more pleased with the results! The antibody exhibited excellent binding specificity, allowing for clear identification of BCMA expression on my target cells. The instructions given were clear and easy to follow, and the support staff went above and beyond to assist me with my questions. The data generated were both reliable and reproducible, making this antibody an invaluable tool in my research on targeted therapies for cancer.
16/Apr/2022
Excellent
Cu***an
Rabbit Anti-BCMA Recombinant Antibody (VS-0723-WK197) (CAT#: VS-0723-WK197)
I recently had the opportunity to work with Creative Biolabs' Rabbit Anti-BCMA Recombinant Antibody in my ELISA assays, and I couldn't be more satisfied with the performance. The antibody demonstrated remarkable specificity, yielding clear and accurate results with minimal cross-reactivity. The provided protocol was intuitive and thorough, allowing for effortless customization to suit my requirements. The validation data provided was invaluable, as it allowed me to fine-tune my assay conditions for optimal performance. This antibody has proven to be an indispensable asset in my research on BCMA quantification, consistently delivering reliable and reproducible results.
22/Mar/2024

rAb Production

Our anti-BCMA recombinant antibodies are produced using advanced biotechnological methods, which involve genetically modified cells that effectively express and secrete antibodies targeting the BCMA protein. This innovative approach ensures efficient and economical production, making our antibodies readily available for various research applications.

Featured Anti-BCMA Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti- BCMA recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-BCMA recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in delivering innovative and high-quality anti-BCMA recombinant antibodies in various formats for research purposes.

Fig.3 BCMA antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-BCMA recombinant antibody production and modalities.

BCMA-Targeted Drug Information

Table 2. Public drug targeting BCMA.

Highest Phase Mechanism of Action Product Category Condition Organization
Launched - 2023 Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269)Signal Transduction Modulators Cancer ImmunotherapyChimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR) Multiple myelomaNeuromyelitis optica Huazhong University of Science and Tech (Originator)IASO BIOInnovent Biologics (Originator)
Launched - 2023 Anti-CD269 (Anti-BCMA)Anti-CD3 (T-Cell Surface Glycoprotein CD3)Signal Transduction ModulatorsT-Cell Engagers Bispecific AntibodiesCancer ImmunotherapyHuman Monoclonal Antibodies Multiple myeloma Pfizer (Originator)
Registered - 2024 Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269) Cancer ImmunotherapyChimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR) Multiple myeloma CARsgen Therapeutics (Originator)Hangzhou Huadong Medicine GroupShanghai Jiao Tong University (SJTU) (Originator)
Pre-Registered Anti-CD269 (Anti-BCMA)Anti-CD3 (T-Cell Surface Glycoprotein CD3)Signal Transduction ModulatorsT-Cell Engagers Bispecific AntibodiesCancer Immunotherapy Allergy, foodChronic kidney diseaseImmunoproliferative DisordersLight chain amyloidosisMultiple myelomaSmoldering myeloma Regeneron (Originator)
Phase III Drugs Targeting T-Cell Surface Glycoprotein CD3Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269)T-Cell Engagers Antibody-Derived Binding ProteinsBispecific AntibodiesCancer ImmunotherapyFusion ProteinsPolypeptides, from 41 AA Light chain amyloidosisMultiple myeloma AbbVie (Originator)TeneoBio (Amgen)
Phase II Drugs Targeting G-Protein Coupled Receptor Family C Group 5 Member D (GPRC5D)Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269)Signal Transduction Modulators Cancer ImmunotherapyChimeric Antigen Receptor-Modified T Cells (CAR T Cells) Multiple myeloma Guangzhou Bio-gene Technology (Originator)
Phase II Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269) Cancer ImmunotherapyChimeric Antigen Receptor-Modified T Cells (CAR T Cells) Autoimmune diseaseMultiple myelomaMyasthenia gravisSystemic lupus erythematosus Cartesian Therapeutics (Originator)Dana-Farber Cancer Institute (Originator)
Phase I/II Anti-CD269 (Anti-BCMA)Anti-CD3 (T-Cell Surface Glycoprotein CD3)Anti-GPRC5D (G-Protein Coupled Receptor Family C Group 5 Member D)Signal Transduction ModulatorsT-Cell Engagers Cancer ImmunotherapyFusion ProteinsPolypeptides, from 41 AATrispecific Antibodies Multiple myeloma Beijing Mabworks Biotech (Originator)KYinno Biotechnology (Originator)
Phase I/II Drugs Targeting FcgammaRIII (FCGR3; CD16)Drugs Targeting Natural Cytotoxicity Triggering Receptor 1 (NCR1; CD335; NKp46)Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269)NK-Cell EngagersSignal Transduction Modulators Cancer ImmunotherapyFusion ProteinsMultispecific AntibodiesPolypeptides, from 41 AASingle-Chain V-Domain Antibody Fragment (scFv) CancerLight chain amyloidosisMultiple myeloma Innate Pharma (Originator)Sanofi (Originator)
Phase I/II Drugs Targeting Tumor Necrosis Factor Receptor Superfamily Member 17 (TNFRSF17, BCMA, CD269) Cancer ImmunotherapyChimeric Antigen Receptor (CAR)-Modified Natural Killer (NK) Cells Multiple myeloma Asclepius (Suzhou) Technology (Originator)Asclepius (Suzhou) Technology Company (Asclepius (Suzhou) Technology)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs offers an extensive selection of high-quality anti-BCMA recombinant antibodies tailored to meet your research needs. Our committed team guarantees timely delivery of both large and small orders, complemented by outstanding customer support. Contact us today to learn how our antibodies can elevate your research projects.

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