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BMP4
Anti-BMP4 Recombinant Antibody Products
- Mouse Anti-BMP4 Recombinant Antibody (clone 3H2) (NEUT-051CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, Neut, WB
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- Mouse Anti-BMP4 Recombinant Antibody (clone CBL815) (NEUT-052CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: Neut, WB
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- Mouse Anti-BMP4 Recombinant Antibody (clone CBL816) (NEUT-053CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, Neut, ELISA
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- Mouse Anti-BMP4 Recombinant Antibody (clone CBL987) (NEUT-054CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, WB, IHC, Neut
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- Rat Anti-BMP4 Recombinant Antibody (clone CBL387) (NEUT-055CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG1
- Application: Neut
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Hepatic stellate cells, Skeletal myocytes, Basal squamous epithelial cells, Pancreatic endocrine cells, Syncytiotrophoblasts)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enhanced (CACO-2, CAPAN-2, Hep G2, OE19, SuSa)
Interaction
Homodimer; disulfide-linked (By similarity). Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Interacts with SOSTDC1. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor BMPR1A (PubMed:8006002). Interacts with type II receptor BMPR2 (PubMed:29212066). Interacts with FSTL1; this interaction inhibits the activation of the BMP4/Smad1/5/8 signaling pathway (PubMed:29212066). Interacts with SCUBE3 (PubMed:33308444).
Molecular function
Cytokine, Developmental protein, Growth factor
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway