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C5AR1

Anti-C5AR1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides an extensive selection of anti-C5AR1 recombinant antibodies, meticulously designed to offer superior specificity and affinity suitable for innovative immunological research and therapeutic applications. Each product is subjected to strict validation processes to guarantee optimal performance in various assays, equipping researchers with the precision and dependability essential for their important investigations.

C5AR1: An Attractive Target for Cancer Therapy

The C5a receptor, also known as complement component 5a receptor 1 (C5AR1) or CD88, is a G protein-coupled receptor essential for transducing the biological responses triggered by the complement fragment C5a. It is involved in driving powerful pro-inflammatory responses and regulating immune functions. Abnormalities in the C5a-C5AR1 signaling pathway are linked to a variety of immune-related disorders, highlighting the importance of therapeutic strategies aimed at inhibiting this pathway for the effective treatment of these conditions.

Alternative Names

C5AR1; complement C5a receptor 1; C5A; C5AR; C5R1; CD88

Background

C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.

Protein class

CD markers, G-protein coupled receptors, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Macrophages, Kupffer cells, Hofbauer cells, Langerhans cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)

Interaction

Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

Anti-C5AR1 rAb Products

Creative Biolabs offers a curated collection of recombinant anti-C5AR1 antibodies, meticulously designed to specifically target and neutralize the C5AR1. Our antibodies are renowned for their exceptional affinity and specificity, ensuring precise binding and potent inhibition. Available in a variety of formats to suit your research needs, these antibodies are ideal for a broad range of immunological applications.

Table 1. Featured anti-C5AR1 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
NEUT-097CQ Rat Anti-C5AR1 Recombinant Antibody (clone 20/70) Mouse Rat IgG2b, κ FC, Block
HPAB-0143-CN Rabbit Anti-C5AR1 Recombinant Antibody Human Rabbit IgG ELISA, FC
HPAB-M0021-YC Mouse Anti-C5AR1 Recombinant Antibody Human Mouse IgG ELISA, FC, Block
HPAB-M0020-YC Mouse Anti-C5AR1 Recombinant Antibody Human Mouse IgG ELISA, FC, Block
HPAB-M0019-YC Mouse Anti-C5AR1 Recombinant Antibody Human Mouse IgG ELISA, FC, Block

Creative Quality Control

Creative Biolabs is a leading provider of premium-quality anti-C5AR1 recombinant antibodies, designed to facilitate groundbreaking immunological research. Leveraging our advanced facilities and stringent quality control processes, we deliver antibodies that consistently meet the highest performance standards. Our dedicated team of scientists is committed to continuous innovation, refining our production techniques, and staying at the forefront of biotechnological advancements.

Customer Reviews

Excellent
Wa***u
Mouse Anti-C5AR1 Recombinant Antibody (clone CBL759) (NEUT-096CQ)
I recently purchased the Mouse Anti-C5AR1 Recombinant Antibody (clone CBL759) from Creative Biolabs for a flow cytometry experiment. The antibody performed exceptionally well in my FC assay, demonstrating high specificity and sensitivity. The staining was clear and consistent, allowing for accurate analysis of C5AR1 expression. I was particularly impressed with the antibody's low background staining, which ensured reliable results. In general, I am extremely pleased with the product's quality and efficacy.
11/Apr/2022
Excellent
Ku***y
Recombinant Mouse Anti-C5AR1 Antibody (NEUT-093CQ)
I used Creative Biolabs' Recombinant Mouse Anti-C5AR1 Antibody for my IHC experiment. It performed exceptionally well, providing clear, specific staining and minimal background. I highly recommend it for C5AR1 research.
20/Nov/2022
Excellent
Da***l
Human Anti-C5AR1 Recombinant Antibody (clone Fab400) (EPAF-0571CQ)
The Anti-C5AR1 Recombinant Antibody from Creative Biolabs proved to be an invaluable tool for my ELISA assay. Its exceptional sensitivity and specificity enabled accurate quantification of C5AR1 protein levels. The assay protocol was straightforward, and the results were highly reproducible.
7/Nov/2023

rAb Production

Our cutting-edge recombinant antibody platform targeting C5AR1 harnesses the power of genetically engineered cells to produce premium antibodies that specifically bind to the C5AR1 protein. This advanced technology ensures a scalable and efficient manufacturing process, guaranteeing a consistent supply for both research applications and therapeutic interventions.

Featured Anti-C5AR1 Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-C5AR1 recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-C5AR1 recombinant antibody production.

rAb Modalities

Creative Biolabs presents an extensive array of top-tier recombinant antibodies aimed at C5AR1, provided in multiple formats to cater to a variety of applications and requirements.

Fig.3 C5AR1 antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-C5AR1 recombinant antibody production and modalities.

C5AR1-Targeted Drug Information

Table 2. Public drug targeting C5AR1.

Highest Phase Mechanism of Action Product Category Condition Organization
Phase II Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Cancer Immunotherapy
Human Monoclonal Antibodies
Bullous pemphigoid
Cancer
Cancer, liver (hepatocellular carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor
Rheumatoid arthritis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Innate Pharma
Novo Nordisk (Originator)
Phase II Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Humanized Monoclonal Antibodies Arthritis
Inflammatory disorders
Rheumatoid arthritis
Systemic lupus erythematosus
G2 Therapies (Originator)
Garvan Institute (Originator)
Novo Nordisk
Phase I Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer
Cancer, solid tumor
HI-Bio
I-Mab Biopharma
MorphoSys (Originator)
Preclinical Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
C5 Expression Inhibitors
Signal Transduction Modulators
Antibodies
Antibody-Oligonucleotide Conjugates (AOCs)
Double-stranded oligoribonucleotide (RNA)
Small Interfering RNA (SiRNAs)
Arthritis University of Colorado (Originator)
Preclinical Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Murine Monoclonal Antibodies Arthritis Novo Nordisk (Originator)
Preclinical C5a Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88) Antagonists
Signal Transduction Modulators
Aptamers
Oligonucleotides
Pegylated Drugs
Systemic inflammatory response syndrome (SIRS) TME Pharma (Originator)
Preclinical Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Murine Monoclonal Antibodies Arthritis G2 Therapies (Originator)
Novo Nordisk
Preclinical Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Murine Monoclonal Antibodies Arthritis G2 Therapies (Originator)
Novo Nordisk
Preclinical C5a Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88) Antagonists
Signal Transduction Modulators
Polypeptides, from 41 AA
Recombinant proteins
Inflammatory disorders
Ischemia-reperfusion injury
Alligator Bioscience (Originator)
Biological Testing Anti-Anaphylatoxin Chemotactic Receptor 1 (C5aR; CD88)
Signal Transduction Modulators
Antibodies Adhesion North China University Science Technol (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Looking for a specialized antibody to fit your research objectives? Get in touch with us to create and manufacture bespoke anti-C5AR1 antibodies tailored to your precise specifications.

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