CACTIN

Formats

Anti-CACTIN Recombinant Antibody Products

Mouse Anti-CACTIN Recombinant Antibody (clone 34G8) (MOB-1533z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a pro-inflammatory-independent manner (PubMed:20829348). Does not interact with RELA NF-kappa-B subunit (PubMed:20829348). Identified in the spliceosome C complex (PubMed:11991638). Interacts with isoform 2 of TRIM39 (via domain B box-type) (PubMed:26363554).

Molecular function

Developmental protein

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