CD19 & FcγRI
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
-
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
Compare
-
- Species Reactivity: Mouse
- Type: Mouse scFv
- Application: FC
Compare
-
- Species Reactivity: Mouse
- Type: Mouse scFv
- Application: FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FC
Compare
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human scFv
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized scFv
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized scFv
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB
Compare
-
- Species Reactivity: Human
- Type: scFv
- Application: WB
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: ELISA, WB, FC, IF
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: FC, in vitro cytotoxic, ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: FC
Compare
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, in vitro cytotoxic, ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: FC
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB
Compare
-
- Species Reactivity: Human
- Type: Fab
- Application: WB
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, FC, IF
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
Compare
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized Fab
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized Fab
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
Compare
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
-
- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: FC
Compare
-
- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: FC
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
-
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, Inhib, ADCC, FuncS
Compare
-
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, Inhib, ADCC, FuncS
Compare
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
Compare
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.