CD19 & FcγRI

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Anti-CD19 & FcγRI Products

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    • Target: CD19
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Target: CD19
    • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Background

CD19: Encodes a B-cell surface receptor involved in antigen signaling. It amplifies B-cell receptor signals to regulate proliferation and differentiation. The protein is essential for humoral immunity. Mutations cause immunodeficiency.
CD19 & FcγRI
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
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