CD3E

CD3E encodes the epsilon chain of the T-cell receptor complex. This gene is involved in T-cell activation and signaling, as it plays a crucial role in initiating the immune response upon antigen recognition. The CD3 complex, consisting of multiple subunits including CD3E, is required for proper T-cell function and development. Mutations in CD3E can lead to immunodeficiencies, highlighting its importance in the immune system.