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For Research Use Only. Not For Clinical Use.
Creative Biolabs is dedicated to providing top-quality anti-CD7 antibodies to support the vital work of researchers in the biomedical field. We recognize the crucial role that targeted antibodies play in advancing scientific discovery, and our products are meticulously designed to meet the highest standards of quality and reliability. With a commitment to excellence, we aim to empower researchers by supplying the tools they need to achieve impactful results in their studies.
CD7 is a cell surface antigen expressed on T cells and natural killer cells. As a target for research, it holds significant importance. In the field of immunology, studying CD7 helps in understanding the development and function of these immune cells. It can provide insights into immune responses and disorders related to T cells and NK cells. In cancer research, CD7 is often a target for immunotherapies as it is overexpressed in certain types of leukemia and lymphomas. Targeting CD7 may offer new treatment strategies for these malignancies. Additionally, understanding CD7 can aid in the development of diagnostic tools and therapies for various immune-mediated diseases.
CD7 molecule; GP40; TP41; Tp40; LEU-9
CD7 is a transmembrane protein that is a member of the immunoglobulin superfamily. CD7 is found on thymocytes and mature T cells. CD7 plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.
CD markers
Intracellular, Membrane (different isoforms)
Group enriched (NK-cells, dendritic cells, T-cells)
Immune cell enhanced (NK-cell)
Cell line enhanced (Hep G2, JURKAT, MOLT-4)
Interacts with SECTM1.
Receptor
We are committed to providing high-quality anti-CD7 recombinant antibody products with the aim of accelerating research and discovery in the field of target-related drugs.
Cat. No. | Product Name | Target Species | Host Species | Applications |
MHH-183-F(E) | Recombinant Human Anti-human CD7 Antibody Fab Fragment | Human | Human | Neut; WB; FuncS |
HPAB-0265-YJ-VHH | Recombinant Camel Anti-CD7 Single Domain Antibody | Human | Camel | ELISA; FC; IF |
FAMAB-0049CQ | Human Anti-CD7 Recombinant Antibody (clone CHT2) | Human | Human | IHC; FC; Block; IF |
FAMAB-0050CQ | Mouse Anti-CD7 Recombinant Antibody (clone RFT2) | Human | Mouse | IHC; FC; Block; IF |
MOB-183 | Recombinant Anti-human CD7 Antibody | Human | Mouse | ELISA; IF; FuncS |
Our team is dedicated to ensuring that the antibody products are of the highest quality, meticulously crafted through advanced technologies and rigorous quality control processes. By offering these top-notch antibodies, we hope to contribute to the advancement of scientific research and the development of more effective drugs targeting CD7.
Fig.1 SDS-PAGE analysis of anti-CD7 antibody
(Cat# MHH-183-F(E), Creative Biolabs).
Fig.2 SEC-HPLC analysis of anti-CD7 antibody
(Cat# MHH-183-F(E), Creative Biolabs).
We have accumulated many years of experience in optimizing processes related to expression vectors, screening transfected cell lines, and purifying antibodies. We provide top-notch services spanning from gene synthesis to antibody production for those in the field of biomedical research.
Featured Anti-CD7 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale recombinant antibody production.
Fig.4 Gram-scale recombinant antibody production
Creative Biolabs strives to offer multiple forms of the recombinant antibody. Whether it's for basic research, drug discovery, or any other scientific pursuit, our antibodies are designed to meet the unique needs of our customers and contribute to the advancement of scientific knowledge.
Fig.5 Full Length Anti-CD7 Recombinant Antibody Production and Modalities
Table 1. Therapeutic approaches targeting CD7 in clinical development.
Research phase | Company | Classification | Indications | Details |
Phase III | Henogen | Fusion Proteins | Graft-versus-host disease | It is a mixture of immunotoxins targeted at CD3 and CD7, consisting of an anti-CD3 mAb (SPV-T3a)-ricin A chain fusion protein and an anti-CD7 mAb (WT1)-ricin A chain fusion protein, in phase III clinical development at Xenikos as an intravenous treatment for steroid-refractory grade III-IV acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. |
Phase II | First Affiliated Hospital Soochow Univ | Chimeric Antigen Receptor-Modified T Cells | Acute lymphocytic leukemia | CD7-CART, T cell targeting CD7 chimeric antigen receptor, is in early clinical development at PersonGen Biomedicine (Suzhou) for the treatment of relapsed / refractory CD7-positive hematolymph system malignant tumor patients. |
Phase I/II | Beam Therapeutics | Chimeric Antigen Receptor-Modified T Cells | Leukemia | It is a quadruplex-edited allogeneic CAR-T cell investigational therapy, is in phase I/II development at Beam Therapeutics for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) as well as relapsed/refractory T cell lymphoblastic lymphoma (T-LL). |
Phase I/II | Wugen | Chimeric Antigen Receptor-Modified T Cells | Acute lymphocytic leukemia | This is a CD7-targeted CAR T-cell therapy consisting of human allogeneic T lymphocytes expressing a CD7-targeted CAR, is being developed by Wugen as treatment of CD7-expressing T-cell leukemias and lymphomas. |
Phase I | Hebei Yanda Lu daopei Hospital | Chimeric Antigen Receptor-Modified T Cells | Lymphoma | It is a cell therapy consisting of edited T cells expressing a universal CAR targeting CD7 linked to an NK inhibitory ligand (NKi) consisting of an EC1-EC2 extracellular domain of E-cadherin, is in early clinical development at Nanjing Bioheng Biotechnology for the treatment of CD7+ relapsed or refractory T-cell acute lymphocytic leukemia. |
Phase I | Gracell Biotechnologies | Chimeric Antigen Receptor-Modified T Cells | B-cell acute lymphocytic leukemia | Gracell Biotechnology (Shanghai) is developing human allogeneic T lymphocytes expressing a universal chimeric antigen receptor (UCAR) targeting CD19. The immunotherapy is in early clinical development for the treatment of pediatric patients with B-cell acute lymphocytic leukemia or B-cell lymphoma. |
Phase I | Gracell Biotechnologies | Chimeric Antigen Receptor-Modified T Cells | Hematologic-blood cancer | It is an off-the-shelf, allogeneic CAR T-cell therapy targeting CD7 developed by Gracell Biotechnologies for the treatment of relapsed or refractory CD7-positive T-cell malignancies. Early clinical trials had been ongoing; however, no recent development has been reported. |
Clinical | Nanjing Bioheng Biotechnology | Chimeric Antigen Receptor-Modified T Cells | T-cell acute lymphocytic leukemia | This is a universal chimeric antigen receptor (CAR) T-cell therapy targeting CD7 developed at Nanjing Biogeng Biotech. The company is evaluating this therapy in clinical studies for the treatment of T-cell acute lymphoblastic leukemia. |
Clinical | Hebei Senlang Biotechnology | Chimeric Antigen Receptor-Modified T Cells | Leukemia; Lymphoma | It is a CAR-T cell therapy targeting T-cell antigen CD7, is in clinical development at Hebei Senlang Biotechnology for the treatment of leukemia. |
If you would like to know more about our anti-CD7 recombinant antibody products or have any questions, please feel free to contact us at any time. Our dedicated team is here to provide comprehensive support and serve you wholeheartedly, ensuring all your research needs are met.