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CD7

Anti-CD7 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is dedicated to providing top-quality anti-CD7 antibodies to support the vital work of researchers in the biomedical field. We recognize the crucial role that targeted antibodies play in advancing scientific discovery, and our products are meticulously designed to meet the highest standards of quality and reliability. With a commitment to excellence, we aim to empower researchers by supplying the tools they need to achieve impactful results in their studies.

CD7: A Cell Surface Antigen in Cancer Disease

CD7 is a cell surface antigen expressed on T cells and natural killer cells. As a target for research, it holds significant importance. In the field of immunology, studying CD7 helps in understanding the development and function of these immune cells. It can provide insights into immune responses and disorders related to T cells and NK cells. In cancer research, CD7 is often a target for immunotherapies as it is overexpressed in certain types of leukemia and lymphomas. Targeting CD7 may offer new treatment strategies for these malignancies. Additionally, understanding CD7 can aid in the development of diagnostic tools and therapies for various immune-mediated diseases.

Alternative Names

CD7 molecule; GP40; TP41; Tp40; LEU-9

Background

CD7 is a transmembrane protein that is a member of the immunoglobulin superfamily. CD7 is found on thymocytes and mature T cells. CD7 plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (NK-cells, dendritic cells, T-cells)

Immune cell specificity

Immune cell enhanced (NK-cell)

Cell line specificity

Cell line enhanced (Hep G2, JURKAT, MOLT-4)

Interaction

Interacts with SECTM1.

Molecular function

Receptor

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Anti-CD7 rAb Products

We are committed to providing high-quality anti-CD7 recombinant antibody products with the aim of accelerating research and discovery in the field of target-related drugs.

Cat. No. Product Name Target Species Host Species Applications
MHH-183-F(E) Recombinant Human Anti-human CD7 Antibody Fab Fragment Human Human Neut; WB; FuncS
HPAB-0265-YJ-VHH Recombinant Camel Anti-CD7 Single Domain Antibody Human Camel ELISA; FC; IF
FAMAB-0049CQ Human Anti-CD7 Recombinant Antibody (clone CHT2) Human Human IHC; FC; Block; IF
FAMAB-0050CQ Mouse Anti-CD7 Recombinant Antibody (clone RFT2) Human Mouse IHC; FC; Block; IF
MOB-183 Recombinant Anti-human CD7 Antibody Human Mouse ELISA; IF; FuncS

Creative Quality Control

Our team is dedicated to ensuring that the antibody products are of the highest quality, meticulously crafted through advanced technologies and rigorous quality control processes. By offering these top-notch antibodies, we hope to contribute to the advancement of scientific research and the development of more effective drugs targeting CD7.

Fig.1 SDS-PAGE analysis of MHH-183-F(E). (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-CD7 antibody
(Cat# MHH-183-F(E), Creative Biolabs).

Fig.2 SEC-HPLC analysis of MHH-183-F(E). (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-CD7 antibody
(Cat# MHH-183-F(E), Creative Biolabs).

Customer Reviews

Excellent
Lu**y
Recombinant Human Anti-human CD7 Antibody Fab Fragment (Cat#: MHH-183-F(E))
In my study focused on hematological malignancies, I used the human anti-human CD7 antibody Fab fragment. Detection was carried out using WB and neutralization assays. WB offered precise visualization of the target protein, while the neutralization assays showcased its potential in modulating disease-related pathways. The antibody fragment was crucial for my research, facilitating my exploration and yielding significant results.
7/May/2022
Excellent
Si*o
Recombinant Camel Anti-CD7 Single Domain Antibody (Cat#: HPAB-0265-YJ-VHH)
I employed the camel anti-CD7 single domain antibody in my research on immune cell characteristics. Using the recommended dilution and concentration ratio, I obtained excellent results. FC enabled clear identification and quantification of cells expressing CD7, providing valuable information about cell populations. IF offered detailed visualization of the localization of CD7 within cells, enhancing my understanding of its functional role.
20/Sep/2022

rAb Production

We have accumulated many years of experience in optimizing processes related to expression vectors, screening transfected cell lines, and purifying antibodies. We provide top-notch services spanning from gene synthesis to antibody production for those in the field of biomedical research.

Featured Anti-CD7 Recombinant Antibody Production PlatformsFig.3 Milligram-scale anti-CD7 recombinant antibody production. (Creative Biolabs Original)
Fig.3 Milligram-scale recombinant antibody production.

Fig.4 Gram-scale anti-CD7 recombinant antibody production. (Creative Biolabs Original)Fig.4 Gram-scale recombinant antibody production

rAb Modalities

Creative Biolabs strives to offer multiple forms of the recombinant antibody. Whether it's for basic research, drug discovery, or any other scientific pursuit, our antibodies are designed to meet the unique needs of our customers and contribute to the advancement of scientific knowledge.

Fig.5 Full Length Anti-CD7 Recombinant Antibody Production and Modalities. (Creative Biolabs Original) Fig.5 Full Length Anti-CD7 Recombinant Antibody Production and Modalities

Drug Information Targeting CD7

Table 1. Therapeutic approaches targeting CD7 in clinical development.

Research phase Company Classification Indications Details
Phase III Henogen Fusion Proteins Graft-versus-host disease It is a mixture of immunotoxins targeted at CD3 and CD7, consisting of an anti-CD3 mAb (SPV-T3a)-ricin A chain fusion protein and an anti-CD7 mAb (WT1)-ricin A chain fusion protein, in phase III clinical development at Xenikos as an intravenous treatment for steroid-refractory grade III-IV acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Phase II First Affiliated Hospital Soochow Univ Chimeric Antigen Receptor-Modified T Cells Acute lymphocytic leukemia CD7-CART, T cell targeting CD7 chimeric antigen receptor, is in early clinical development at PersonGen Biomedicine (Suzhou) for the treatment of relapsed / refractory CD7-positive hematolymph system malignant tumor patients.
Phase I/II Beam Therapeutics Chimeric Antigen Receptor-Modified T Cells Leukemia It is a quadruplex-edited allogeneic CAR-T cell investigational therapy, is in phase I/II development at Beam Therapeutics for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) as well as relapsed/refractory T cell lymphoblastic lymphoma (T-LL).
Phase I/II Wugen Chimeric Antigen Receptor-Modified T Cells Acute lymphocytic leukemia This is a CD7-targeted CAR T-cell therapy consisting of human allogeneic T lymphocytes expressing a CD7-targeted CAR, is being developed by Wugen as treatment of CD7-expressing T-cell leukemias and lymphomas.
Phase I Hebei Yanda Lu daopei Hospital Chimeric Antigen Receptor-Modified T Cells Lymphoma It is a cell therapy consisting of edited T cells expressing a universal CAR targeting CD7 linked to an NK inhibitory ligand (NKi) consisting of an EC1-EC2 extracellular domain of E-cadherin, is in early clinical development at Nanjing Bioheng Biotechnology for the treatment of CD7+ relapsed or refractory T-cell acute lymphocytic leukemia.
Phase I Gracell Biotechnologies Chimeric Antigen Receptor-Modified T Cells B-cell acute lymphocytic leukemia Gracell Biotechnology (Shanghai) is developing human allogeneic T lymphocytes expressing a universal chimeric antigen receptor (UCAR) targeting CD19. The immunotherapy is in early clinical development for the treatment of pediatric patients with B-cell acute lymphocytic leukemia or B-cell lymphoma.
Phase I Gracell Biotechnologies Chimeric Antigen Receptor-Modified T Cells Hematologic-blood cancer It is an off-the-shelf, allogeneic CAR T-cell therapy targeting CD7 developed by Gracell Biotechnologies for the treatment of relapsed or refractory CD7-positive T-cell malignancies. Early clinical trials had been ongoing; however, no recent development has been reported.
Clinical Nanjing Bioheng Biotechnology Chimeric Antigen Receptor-Modified T Cells T-cell acute lymphocytic leukemia This is a universal chimeric antigen receptor (CAR) T-cell therapy targeting CD7 developed at Nanjing Biogeng Biotech. The company is evaluating this therapy in clinical studies for the treatment of T-cell acute lymphoblastic leukemia.
Clinical Hebei Senlang Biotechnology Chimeric Antigen Receptor-Modified T Cells Leukemia; Lymphoma It is a CAR-T cell therapy targeting T-cell antigen CD7, is in clinical development at Hebei Senlang Biotechnology for the treatment of leukemia.

If you would like to know more about our anti-CD7 recombinant antibody products or have any questions, please feel free to contact us at any time. Our dedicated team is here to provide comprehensive support and serve you wholeheartedly, ensuring all your research needs are met.

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