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CEBPA
Anti-CEBPA Recombinant Antibody Products
- AbPlus™ Anti-CEBPA Magnetic Beads (VS-0724-YC401) (VS-0724-YC401)
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- Target: CEBPA
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Suprabasal keratinocytes, Hepatocytes, Distal enterocytes, Hofbauer cells)
Immune cell specificity
Group enriched (basophil, non-classical monocyte, intermediate monocyte, classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (BEWO, Hep G2, NB-4, THP-1, U-937)
Interaction
Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (By similarity). Interacts with PRDM16 (By similarity). Interacts with UBN1 (PubMed:10725330). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812). Interacts with RB1 (PubMed:15107404). Interacts (when phosphorylated at SER-190) with CDK2, CDK4, E2F4 and SMARCA2 (PubMed:15107404). Interacts with SREBPF1 (By similarity). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (By similarity). Interacts with SIX1 (PubMed:27923061). Interacts (via recognition sequence) with TRIB1 (PubMed:20410507, PubMed:26455797). [Isoform 1]: Interacts with TAF1A and UBTF. [Isoform 4]: Interacts with TAF1A and UBTF (PubMed:20075868). Interacts with NPM1 (PubMed:20075868). (Microbial infection) Interacts with HBV protein X.
Molecular function
Activator, Developmental protein, DNA-binding
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