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Anti-CGRP Recombinant Antibody Products

Anti-CGRP Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is a leading provider of anti-CGRP recombinant antibodies, offering a diverse selection tailored to support global cancer research. Our highly skilled team is dedicated to delivering high-quality antibodies and comprehensive technical support, ensuring researchers have the necessary tools for their projects. Additionally, we provide extensive validated data to serve as valuable references, facilitating informed decision-making and accelerating research progress.

CGRP: A Potential Therapeutic Target for Cardiac- and Neuro- Disorders

CGRP is a potent vasodilator and neuroprotective agent with implications for cardiovascular health and wound healing. Evidence shows that dysregulation of CGRP levels has been implicated in various pathological states, including migraine, temporomandibular joint disorder, and cardiovascular diseases. Preclinical evidence suggests a role for CGRP in migraine pathogenesis, where its release from trigeminal nerve endings can induce meningeal vasodilation and inflammation. Given its potential as a therapeutic target, further research into CGRP's biological functions and interactions is warranted.

Alternative Names

Calcitonin gene-related peptide; CALC1.

Background

Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide, which is primarily localized to C and Aδ sensory fibers. These fibers display a wide innervation throughout the body, with extensive perivascular localization, and have a dual role in sensory (nociceptive) and efferent (effector) functions.

Anti-CGRP rAb Products

Creative Biolabs stands at the forefront of biotechnological innovation, providing top-notch anti-CGRP recombinant antibodies tailored for cutting-edge cancer research worldwide. Our antibodies precisely recognize the CGRP protein, empowering researchers to explore its significant influence on tumor growth and advancement. Available in multiple formats to meet various experimental needs, our anti-CGRP antibodies are essential assets for decoding the complexities of cancer biology and advancing therapeutic strategies.

Table 1. Featured anti-CGRP recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
TAB-425CQ Anti-Human CGRP Recombinant Antibody (Eptinezumab) Human Human IgG1, κ ELISA, IHC, IF, IP, FC, Inhib, etc.
TAB-428CQ Anti-Human CGRP Recombinant Antibody (Fremanezumab) Human Human IgG2, κ ELISA, IHC, FC, IP, IF, Inhib, FuncS
TAB-429CQ Anti-Human CGRP Recombinant Antibody (Galcanezumab) Human Human IgG4, κ ELISA, IHC, FC, IP, IF, Inhib, PK, PD
HPAB-2072LY Mouse Anti-CGRP Recombinant Antibody Human Mouse IgG ELISA
HPAB-3115LY Human Anti-CGRP Recombinant Antibody (clone Ab14) Human Human IgG ELISA

Creative Quality Control

Creative Biolabs is dedicated to providing global customers with a wide array of high-quality anti-CGRP antibodies. Each antibody is subjected to stringent testing protocols to guarantee superior performance and reliability in various applications. Our steadfast commitment to excellence ensures that all products comply with the highest industry standards, enabling researchers to achieve consistent and dependable results in their scientific studies.

Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-425CQ, Creative Biolabs).

Fig.2 SEC-HPLC analysis. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-CGRP antibody
(Cat# TAB-425CQ, Creative Biolabs).

Fig.3 SDS-PAGE analysis. (Creative Biolabs Original)Fig.3 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-428CQ, Creative Biolabs).

Fig.4 SEC-HPLC analysis. (Creative Biolabs Original)Fig.4 SEC-HPLC analysis of anti-CGRP antibody
(Cat# TAB-428CQ, Creative Biolabs).

Fig.5 SDS-PAGE analysis. (Creative Biolabs Original)Fig.5 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-429CQ, Creative Biolabs).

Fig.6 WB analysis. (Creative Biolabs Original)Fig.6 WB analysis of anti-CGRP antibody
(Cat# TAB-429CQ, Creative Biolabs).

Customer Reviews

Excellent
Ev***n
Mouse Anti-CGRP Recombinant Antibody (HPAB-1075-FY) (CAT#: HPAB-1075-FY)
For my ELISA experiments, I have been using Creative Biolabs' anti-CGRP recombinant antibody, and I am extremely pleased with how well it works. These antibodies demonstrate remarkable specificity and sensitivity, enabling me to accurately identify even minimal CGRP concentrations in my samples. The protocols provided are straightforward and user-friendly, making the process seamless. Furthermore, the technical support team is highly responsive and knowledgeable, readily assisting with any inquiries I encounter. I wholeheartedly endorse these antibodies to fellow researchers.
26/Apr/2022
Excellent
Mo***a
Mouse Anti-CGRP Recombinant Antibody (HPAB-2072LY) (CAT#: HPAB-2072LY)
I have consistently relied on Creative Biolabs' anti-CGRP recombinant antibodies for my ELISA assays over several years, and they have consistently delivered reliable and accurate results. The antibodies exhibit excellent sensitivity and specificity, allowing for precise quantification of CGRP levels in various biological matrices.
17/Jun/2023
Excellent
Je***e
Human Anti-CGRP Recombinant Antibody (HPAB-0099CQ) (HPAB-0099CQ)
I've been using Creative Biolabs' anti-CGRP antibodies for a blocking assay, and they've been a total lifesaver! The antibodies are super effective at blocking CGRP activity, and the protocols are easy to follow. I'd definitely recommend these to anyone researching CGRP.
21/Mar/2024

rAb Production

Creative Biolabs applies cutting-edge recombinant antibody technology to produce extremely effective and adaptable anti-CGRP antibodies. Our platform employs genetic engineering approaches to generate antibodies with high specificity, affinity, and stability, designed to satisfy a variety of research demands. This novel technique enables us to provide excellent-quality anti-CGRP antibodies for further scientific research.

Featured Anti-CGRP Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-CGRP recombinant antibody production.

Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-CGRP recombinant antibody production.

rAb Modalities

Creative Biolabs delivers a comprehensive line of premium anti-CGRP recombinant antibodies with multiple formats to aid in customers’ meaningful projects.

Fig.9 CGRP antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-CGRP recombinant antibody production and modalities.

CGRP-Targeted Drug Information

Table 2. Public drug targeting CGRP.

Highest Phase Mechanism of Action Product Category Condition Organization
Launched - 2020 Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1)
Anti-CALCRL (Calcitonin Gene-Related Peptide Receptor; CGRPR)
Signal Transduction Modulators
Humanized Monoclonal Antibodies Cluster headache
Migraine
Polyneuropathy
Alder Biopharmaceuticals (Lundbeck)
Lundbeck (Originator)
Launched - 2018 Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Human Monoclonal Antibodies Angina pectoris, stable
Cluster headache
Hot flushes
Joint disorder, temporomandibular
Migraine
Pain, neuropathic
Rosacea
Traumatic brain injury
Amgen (Originator)
Novartis
Phase II Calcitonin Receptor (CALCR; CT-R) Agonists
Signal Transduction Modulators
Calcitonin
Polypeptides, from 10 AA to 40 AA
Recombinant proteins
Bone disorders
Osteoporosis
Daiichi Sankyo (Originator)
Phase I Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Non-Antiinfective Vaccines
Subunit Vaccines
Migraine Vaxxinity (Originator)
Discontinued Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1)
Anti-IL-23 (Interleukin-23)
Signal Transduction Modulators
Bispecific Antibodies Autoimmune disease Lilly (Originator)
Preclinical Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Murine Monoclonal Antibodies Pain, neuropathic Osaka University
Preclinical Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Humanized Monoclonal Antibodies Migraine Glostrup Hospital (Originator)
Lundbeck (Originator)
Preclinical Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1)
Glucose Lowering Agents
Monoclonal Antibodies Diabetes Astellas Pharma (Originator)
Preclinical Drugs Targeting Calcitonin, Calcitonin Gene-Related Peptide, Amylin and Adrenomedullin Receptors
Signal Transduction Modulators
Macrocyclic Peptides
Peptides
Polypeptides, from 10 AA to 40 AA
Obesity Nordic Bioscience (Originator)
Biological Testing Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1)
Anti-PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide; ADCYAP1)
Antibody-Derived Binding Proteins
Bispecific Antibodies
Bispecific Antibody Fusions
Migraine Jiangsu Hengrui (Originator)
Shanghai Hengrui (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is a leading provider of innovative antibody solutions, combining a robust theoretical framework with extensive practical expertise. Our high-quality, low-cost anti-CGRP antibodies are engineered to fulfill the stringent standards of current research. Please contact us to learn more about our broad product range and how our antibodies might help you further your study.

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