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For Research Use Only. Not For Clinical Use.
Creative Biolabs is a leading provider of anti-CGRP recombinant antibodies, offering a diverse selection tailored to support global cancer research. Our highly skilled team is dedicated to delivering high-quality antibodies and comprehensive technical support, ensuring researchers have the necessary tools for their projects. Additionally, we provide extensive validated data to serve as valuable references, facilitating informed decision-making and accelerating research progress.
CGRP is a potent vasodilator and neuroprotective agent with implications for cardiovascular health and wound healing. Evidence shows that dysregulation of CGRP levels has been implicated in various pathological states, including migraine, temporomandibular joint disorder, and cardiovascular diseases. Preclinical evidence suggests a role for CGRP in migraine pathogenesis, where its release from trigeminal nerve endings can induce meningeal vasodilation and inflammation. Given its potential as a therapeutic target, further research into CGRP's biological functions and interactions is warranted.
Calcitonin gene-related peptide; CALC1.
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide, which is primarily localized to C and Aδ sensory fibers. These fibers display a wide innervation throughout the body, with extensive perivascular localization, and have a dual role in sensory (nociceptive) and efferent (effector) functions.
Creative Biolabs stands at the forefront of biotechnological innovation, providing top-notch anti-CGRP recombinant antibodies tailored for cutting-edge cancer research worldwide. Our antibodies precisely recognize the CGRP protein, empowering researchers to explore its significant influence on tumor growth and advancement. Available in multiple formats to meet various experimental needs, our anti-CGRP antibodies are essential assets for decoding the complexities of cancer biology and advancing therapeutic strategies.
Table 1. Featured anti-CGRP recombinant antibody products at Creative Biolabs.
Cat. No. | Product Name | Target Species | Host Species | Applications |
TAB-425CQ | Anti-Human CGRP Recombinant Antibody (Eptinezumab) | Human | Human IgG1, κ | ELISA, IHC, IF, IP, FC, Inhib, etc. |
TAB-428CQ | Anti-Human CGRP Recombinant Antibody (Fremanezumab) | Human | Human IgG2, κ | ELISA, IHC, FC, IP, IF, Inhib, FuncS |
TAB-429CQ | Anti-Human CGRP Recombinant Antibody (Galcanezumab) | Human | Human IgG4, κ | ELISA, IHC, FC, IP, IF, Inhib, PK, PD |
HPAB-2072LY | Mouse Anti-CGRP Recombinant Antibody | Human | Mouse IgG | ELISA |
HPAB-3115LY | Human Anti-CGRP Recombinant Antibody (clone Ab14) | Human | Human IgG | ELISA |
Creative Biolabs is dedicated to providing global customers with a wide array of high-quality anti-CGRP antibodies. Each antibody is subjected to stringent testing protocols to guarantee superior performance and reliability in various applications. Our steadfast commitment to excellence ensures that all products comply with the highest industry standards, enabling researchers to achieve consistent and dependable results in their scientific studies.
Fig.1 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-425CQ, Creative Biolabs).
Fig.2 SEC-HPLC analysis of anti-CGRP antibody
(Cat# TAB-425CQ, Creative Biolabs).
Fig.3 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-428CQ, Creative Biolabs).
Fig.4 SEC-HPLC analysis of anti-CGRP antibody
(Cat# TAB-428CQ, Creative Biolabs).
Fig.5 SDS-PAGE analysis of anti-CGRP antibody
(Cat# TAB-429CQ, Creative Biolabs).
Fig.6 WB analysis of anti-CGRP antibody
(Cat# TAB-429CQ, Creative Biolabs).
Creative Biolabs applies cutting-edge recombinant antibody technology to produce extremely effective and adaptable anti-CGRP antibodies. Our platform employs genetic engineering approaches to generate antibodies with high specificity, affinity, and stability, designed to satisfy a variety of research demands. This novel technique enables us to provide excellent-quality anti-CGRP antibodies for further scientific research.
Featured Anti-CGRP Recombinant Antibody Production Platforms
Fig.7 Milligram-scale anti-CGRP recombinant antibody production.
Fig.8 Gram-scale anti-CGRP recombinant antibody production.
Creative Biolabs delivers a comprehensive line of premium anti-CGRP recombinant antibodies with multiple formats to aid in customers’ meaningful projects.
Fig.9 Full-length anti-CGRP recombinant antibody production and modalities.
Table 2. Public drug targeting CGRP.
Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
Launched - 2020 |
Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Anti-CALCRL (Calcitonin Gene-Related Peptide Receptor; CGRPR) Signal Transduction Modulators |
Humanized Monoclonal Antibodies |
Cluster headache Migraine Polyneuropathy |
Alder Biopharmaceuticals (Lundbeck) Lundbeck (Originator) |
Launched - 2018 | Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) | Human Monoclonal Antibodies |
Angina pectoris, stable Cluster headache Hot flushes Joint disorder, temporomandibular Migraine Pain, neuropathic Rosacea Traumatic brain injury |
Amgen (Originator) Novartis |
Phase II |
Calcitonin Receptor (CALCR; CT-R) Agonists Signal Transduction Modulators |
Calcitonin Polypeptides, from 10 AA to 40 AA Recombinant proteins |
Bone disorders Osteoporosis |
Daiichi Sankyo (Originator) |
Phase I | Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) |
Non-Antiinfective Vaccines Subunit Vaccines |
Migraine | Vaxxinity (Originator) |
Discontinued |
Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Anti-IL-23 (Interleukin-23) Signal Transduction Modulators |
Bispecific Antibodies | Autoimmune disease | Lilly (Originator) |
Preclinical | Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) | Murine Monoclonal Antibodies | Pain, neuropathic | Osaka University |
Preclinical | Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) | Humanized Monoclonal Antibodies | Migraine |
Glostrup Hospital (Originator) Lundbeck (Originator) |
Preclinical |
Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Glucose Lowering Agents |
Monoclonal Antibodies | Diabetes | Astellas Pharma (Originator) |
Preclinical |
Drugs Targeting Calcitonin, Calcitonin Gene-Related Peptide, Amylin and Adrenomedullin Receptors Signal Transduction Modulators |
Macrocyclic Peptides Peptides Polypeptides, from 10 AA to 40 AA |
Obesity | Nordic Bioscience (Originator) |
Biological Testing |
Anti-CALCA (Calcitonin Gene-Related Peptide 1; CALC1) Anti-PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide; ADCYAP1) |
Antibody-Derived Binding Proteins Bispecific Antibodies Bispecific Antibody Fusions |
Migraine |
Jiangsu Hengrui (Originator) Shanghai Hengrui (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Creative Biolabs is a leading provider of innovative antibody solutions, combining a robust theoretical framework with extensive practical expertise. Our high-quality, low-cost anti-CGRP antibodies are engineered to fulfill the stringent standards of current research. Please contact us to learn more about our broad product range and how our antibodies might help you further your study.