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Anti-CLDN6 Recombinant Antibody Products

Anti-CLDN6 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers a range of recombinant antibodies targeting CLDN6, crafted to address the varying needs of biomedical researchers and institutions. Utilizing cutting-edge technology, these antibodies ensure superior specificity and consistent performance across diverse applications. With a focus on advancing scientific discovery, these tools provide valuable support in the investigation of CLDN6's role in both health and disease. Choose Creative Biolabs to enhance your research with our innovative recombinant antibody offerings.

CLDN6: A Significant Target in Cancer Disease

CLDN6 (Claudin 6) is a tight junction protein. It has emerged as an important target in biomedical research. CLDN6 is often overexpressed in certain cancers, making it a potential target for cancer therapy. Research on CLDN6 can help in understanding the mechanisms of cancer development and progression. By targeting CLDN6, researchers may be able to develop novel therapeutic strategies for cancer treatment, such as targeted drugs or immunotherapies. Additionally, studying CLDN6 may also provide insights into normal physiological processes involving tight junctions and cell adhesion.

Alternative Names

claudin 6

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Cytotrophoblasts, Ductal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, CACO-2, NTERA-2, SuSa)

Interaction

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).

Molecular function

Host cell receptor for virus entry, Receptor

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Anti-CLDN6 rAb Products

Our premium recombinant antibodies targeting CLDN6 are designed to accelerate research and facilitate the discovery of therapeutic agents related to this crucial target.

Cat. No. Product Name Target Species Host Species Applications
TAB-510LC Mouse Anti-CLDN6 Recombinant Antibody Human Mouse Cyt; FC; FuncS
TAB-507LC Mouse Anti-CLDN6 Recombinant Antibody Human Mouse Cyt; FC; FuncS
HPAB-0078-FY Mouse Anti-CLDN6 Recombinant Antibody Human Mouse Active
HPAB-1496-FY Mouse Anti-CLDN6 Recombinant Antibody Human Mouse ELISA; FC
HPAB-1497-FY Mouse Anti-CLDN6 Recombinant Antibody Human Mouse ELISA; FC

Creative Quality Control

To meet the high expectations of our customers for antibody quality, we have established a rigorous and comprehensive quality management system. By adhering to the strictest standards, we ensure the reliability and consistency of our products, providing researchers with dependable tools that support and accelerate scientific advancements.

Fig.1 SDS-PAGE analysis of TAB-510LC. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-CLDN6 antibody
(Cat# TAB-510LC, Creative Biolabs).

Fig.2 SEC-HPLC analysis of TAB-510LC. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-CLDN6 antibody
(Cat# TAB-510LC, Creative Biolabs).

Fig.3 Lectin ELISA analysis of AFC-160CL. (Creative Biolabs Original)Fig.3 Lectin ELISA analysis of anti-CLDN6 antibody
(Cat# AFC-160CL, Creative Biolabs).

Customer Reviews

Excellent
Si**s
Mouse Anti-CLDN6 Recombinant Antibody (Cat#: TAB-510LC)
The recombinant mouse anti-CLDN6 antibody stands out for its exceptional stability, making it both reliable and easy to use. Its strong binding to CLDN6 has significantly advanced my research, proving to be an invaluable and trustworthy tool that I am thoroughly pleased with.
23/Jun/2021
Excellent
Ar**h
Mouse Anti-CLDN6 Recombinant Antibody (Cat#: HPAB-1496-FY)
The recombinant mouse anti-CLDN6 antibody was employed to assess its binding affinity to the CLDN6 protein in cells. In flow cytometry (FC) experiments, it aids in examining CLDN6 expression across various cell types. In ELISA, the antibody demonstrates excellent specificity and sensitivity for detecting CLDN6 protein levels.
18/Aug/2022

rAb Production

With years of extensive experience in process optimization, we are dedicated to offering comprehensive solutions, from gene synthesis to antibody production. Serving as a trusted partner for biomedical researchers, we focus on delivering exceptional results to support and advance their critical research initiatives.

Featured Anti-CLDN6 Recombinant Antibody Production PlatformsFig.4 Milligram-scale anti-CLDN6 recombinant antibody production. (Creative Biolabs Original)
Fig.4 Milligram-scale recombinant antibody production.

Fig.5 Gram-scale anti-CLDN6 recombinant antibody production. (Creative Biolabs Original)Fig.5 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is fully committed to offering researchers high-quality recombinant antibodies in a wide variety of formats. Our goal is to cater to the unique and diverse needs of our customers. Recognizing the vital role that quality antibodies play in research, we strive to provide products that not only meet the highest standards but also come in convenient formats, ideal for different experimental setups.

Fig.6 Full Length Anti-CLDN6 Recombinant Antibody Production and Modalities. (Creative Biolabs Original) Fig.6 Full LengthAnti-CLDN6 Recombinant Antibody Production and Modalities.

Drug Information Targeting CLDN6

Table 1. Therapeutic approaches targeting CLDN6 in clinical development.

Research phase Company Classification Indications Details
Phase I/II BioNTech Biologics Cancer This is a bispecific antibody targeting claudin-6 (CLDN6) and CD3, is in early clinical development at BioNTech for the treatment of CLDN-6-positive advanced solid tumors.
Phase I/II BioNTech Biologics Cancer It is a CAR-T cell therapy targeting CLDN6 in early clinical development at BioNTech for the treatment of solid tumors.
Phase I TORL Biotherapeutics Drug Conjugates Cancer This is an antibody-drug conjugate targeting the tumor specific antigen claudin 6 (CLDN6), is in early clinical development at TORL Biotherapeutics for the treatment of advanced solid tumors.
Phase I Chugai Pharmaceutical Biologics Cancer; Solid tumor It is a trispecific antibody targeting CLDN6, CD3 and CD137 developed at Chugai Pharmaceutical in early phase clinical trials for the intravenous treatment of CLDN6-positive solid tumor.
Phase I Amgen Biologics Cancer This is a bispecific T cell engager (BiTE) targeting claudin 6 (CLDN6) and CD3 in early clinical development at Amgen for the treatment of patients with locally advanced or metastatic malignant solid tumors, including non-squamous non-small cell lung cancer (NSCLC) and epithelial ovarian cancer.

In case you require additional information about anti-CLDN6 recombinant antibody products, feel free to reach out to us. Our team is ready to provide you with the assistance you need, and we look forward to establishing a collaborative relationship that benefits both parties in advancing research efforts.

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