Anti-COMT Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs has partnered with you to provide a highly specific anti-COMT recombinant antibody. Catechol-O-methyltransferase (COMT) is a key enzyme in the metabolism of catecholamine neurotransmitters and is an important modulator of dopamine and norepinephrine neurotransmission in the brain. Our validated antibodies are a powerful tool for studying pain, cognition, and Parkinson’s disease and the discovery of new CNS active drugs.

COMT: A Key Regulator of Catecholamine Neurotransmitters

Catechol-O-methyltransferase (COMT) is one of the two primary enzymes responsible for the breakdown of catecholamines including the neurotransmitters dopamine, norepinephrine, and epinephrine. COMT has two forms: a soluble cytosolic form (S-COMT) and a membrane-bound form (MB-COMT). In the brain, particularly in the prefrontal cortex where dopamine transporters are limited, COMT is the predominant mechanism for dopamine clearance from the synapse. A functional genetic polymorphism in COMT (Val158Met) results in up to a 4-fold difference in enzyme activity. This polymorphism has been associated with interindividual differences in cognition, pain sensitivity, and risk for several psychiatric disorders.

Alternative Names

Catechol O-methyltransferase; EC 2.1.1.6; COMT

Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Anti-COMT rAb Products

Our anti-COMT recombinant antibodies are engineered for superior specificity and performance and were thoroughly validated for specific detection of both the S-COMT and MB-COMT isoforms. The rAb was optimized for Western Blot to study its expression and correlate genotype with protein levels as well as IHC to examine its localization throughout the brain. Our validated rAbs offer the specificity and performance you can rely on for your neuropharmacology research.

Table 1. Featured anti-COMT recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to scientific integrity. We ensure the production of our anti-COMT recombinant antibodies with a rigorous quality control process. Every lot is tested for purity and specificity as well as consistent performance across validated applications to make sure you always receive a reagent of the highest quality.

Customer Reviews

rAb Production

Creative Biolabs is dedicated to supporting the highly specialized field of neuroscience by using the latest production platforms. We express our anti-COMT recombinant antibodies in systems optimized to ensure the antibodies recognize the native enzyme to provide you with a highly specific and active tool.

Featured Anti-COMT Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-COMT recombinant antibody production.

Fig.4 Gram-scale anti-COMT recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to facilitating scientific discovery through highly flexible antibody solutions. Our anti-COMT recombinant antibodies are available in a variety of formats to meet the needs of your research and help researchers around the world study this important neurotransmitter-metabolizing enzyme.

Fig.5 Full-length anti-COMT recombinant antibody production and modalities.

Creative Biolabs is your trusted partner for neuroscience and pharmacology research with a highly specific recombinant anti-COMT antibody. We have you covered with a broad portfolio of validated tools and the rigorous validation process you can count on. Get in touch with our team of scientific experts today.