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For Research Use Only. Not For Clinical Use.
Membrane
Group enriched (Sertoli cells, Oligodendrocyte precursor cells, Smooth muscle cells)
Not detected in immune cells
Cell line enhanced (BJ, SK-MEL-30, U-138 MG, WM-115)
Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. (Microbial infection) Interacts with C.difficile toxin TcdB, suggesting that it may act as a receptor for TcdB.
Developmental protein, Transducer