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CST1

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For Research Use Only. Not For Clinical Use.


Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Collecting duct cells, Glandular and luminal cells, Cholangiocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (RT4)

Molecular function

Protease inhibitor, Thiol protease inhibitor

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