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DACH1
Loading...Anti-DACH1 Products
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC, IP
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- Anti-DACH1 Immunohistochemistry Kit (VS-0325-XY614)
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- Species Reactivity: Human, Mouse, Rat
- Target: DACH1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Muller glia cells, Microglial cells, Late spermatids, Early spermatids, Horizontal cells, Excitatory neurons, Spermatocytes)
Immune cell specificity
Group enriched (eosinophil, plasmacytoid DC, NK-cell, basophil)
Cell line specificity
Cell line enhanced (AF22, HAP1, HEK93, HL-60, NB-4, SCLC-21H, SH-SY5Y, THP-1)
Interaction
Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4.
Molecular function
Activator, Developmental protein, DNA-binding, Repressor
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