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DHRS2

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Protein class

Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Urothelial cells, Syncytiotrophoblasts, Extravillous trophoblasts, Theca cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (Hep G2, RT4, SK-BR-3, U-2 OS)

Interaction

Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.

Molecular function

Oxidoreductase

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