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DLK1

Anti-DLK1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is fully committed to advancing the research and discovery of the target DLK1. By offering exceptional, state-of-the-art recombinant antibodies tailored specifically for DLK1, we aim to make a significant impact on scientific progress. Our innovative products utilize the latest technology to guarantee high specificity and reliability, empowering researchers to achieve groundbreaking results in their studies. With a strong emphasis on quality and performance, we are dedicated to supporting your research efforts and enhancing our understanding of the crucial roles DLK1 plays in various biological processes.

DLK1: A Significant Target in Cancer or Neurodegenerative Disorders

The target DLK1, a transmembrane protein expressed in multiple tissues and cell types, is involved in various biological processes including cell differentiation, proliferation, apoptosis, and tissue regeneration. Research on DLK1 is significant as it can offer insights into embryonic development and tissue homeostasis. Additionally, it has been implicated in several diseases such as cancer, neurodegenerative disorders, and metabolic disorders. Thus, understanding its role in these diseases may lead to the development of new diagnostic and therapeutic strategies. Moreover, DLK1 may serve as a potential target for drug development. Targeting it with specific inhibitors or antibodies could have therapeutic benefits in diseases where it is overexpressed or dysregulated. In conclusion, DLK1 is an important research target with significant implications for human health.

Alternative Names

Delta like non-canonical Notch ligand 1; DLK; DLK-1; Delta1; FA1; PREF1; Pref-1; ZOG; pG2

Background

This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that function as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing uniparental disomy and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Skeletal myocytes, Leydig cells, Fibroblasts, Exocrine glandular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, Hep G2, SH-SY5Y)

Interaction

Monomer. Interacts with SH3RF2 (By similarity).

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Anti-DLK1 rAb Products

We are dedicated to offering high-quality and superior antibody products. These are intended to satisfy the research requirements of a broad spectrum of researchers when it comes to the target DLK1 and its functions. Our goal is to assist their scientific investigations and promote progress in this area.

Cat. No. Product Name Target Species Host Species Applications
TAB-206MZ Anti-Human DLK1 Recombinant Antibody (B09) Human Human ELISA; WB; IP
TAB-207MZ Anti-Human DLK1 Recombinant Antibody (A04) Human Human ELISA; WB; IP
HPAB-0789-CN Mouse Anti-DLK1 Recombinant Antibody Human Mouse ELISA; FC; IHC
TAB-203MZ Mouse Anti-DLK1 Recombinant Antibody Human Mouse FC; FuncS
TAB-204MZ Mouse Anti-DLK1 Recombinant Antibody Human Mouse FC; FuncS

Creative Quality Control

To fulfill the needs of our customers, we have implemented a series of rigorous quality management systems throughout the production process of antibody products to guarantee their superior quality.

Fig.1 ELISA analysis of TAB-206MZ. (Creative Biolabs Original)Fig.1 ELISA analysis of anti-DLK1 antibody (Cat# TAB-206MZ, Creative Biolabs).

Customer Reviews

Excellent
A**ry
Anti-Human DLK1 Recombinant Antibody (B09) (Cat#: TAB-206MZ)
As a customer, I utilized the anti-human DLK1 recombinant antibody for my study. In my experiments, this antibody was applied to detect the presence of DLK1 in particular tissues. When used in WB and IP assays, it demonstrated remarkable specificity, with a specificity rate of over 95%. The sensitivity was also excellent, as it could detect even low levels of DLK1. The results were accurate and dependable, helping me gain a deeper understanding of DLK1's function in those tissues.
17/Apr/2023
Excellent
L**as
Mouse Anti-DLK1 Recombinant Antibody (Cat#: HPAB-0789-CN)
As a research enthusiast, I made use of the mouse anti-DLK1 recombinant antibody in my experiments. I utilized it to examine DLK1 levels in specific cells and tissues. When put to the test via FC and immunohistochemistry, this antibody exhibited exceptional specificity and sensitivity. In FC experiments, it effectively differentiated cells with different expressions of DLK1. With IHC, it offered clear and distinct staining results, facilitating my understanding of DLK1's distribution. The antibody's performance was truly remarkable and crucial for the success of my research.
9/Dec/2023

rAb Production

We provide comprehensive one-stop services that cover an extensive range from gene synthesis to the production of high-quality recombinant antibodies. Our team of experts is committed to ensuring every step is carried out with excellence. Thanks to this extensive service offering, we are entirely capable of providing customers with superior antibody production services that meet their diverse needs.

Featured Anti-DLK1 Recombinant Antibody Production PlatformsFig.2 Milligram-scale anti-DLK1 recombinant antibody production. (Creative Biolabs Original)
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale anti-DLK1 recombinant antibody production. (Creative Biolabs Original)Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is firmly committed to providing researchers with the most comprehensive and cutting-edge high-quality recombinant antibodies in diverse formats. We strive to meet the diverse needs of scientific research by offering a wide range of antibody options to facilitate advanced research endeavors.

Fig.4 Full Length Anti-DLK1 Recombinant Antibody Production and Modalities. (Creative Biolabs Original)Fig.4 Full Length Anti-DLK1 Recombinant Antibody Production and Modalities.

Drug Information Targeting DLK1

Table 1. Therapeutic approaches targeting DLK1 in clinical development.

Research phase Company Classification Indications Details
Phase I TORL Biotherapeutics Antibody-Drug Conjugates (ADCs) Cancer It is an antibody-drug conjugate targeting delta like non-canonical notch ligand 1 (DLK1) in early clinical development at TORL Biotherapeutics for the treatment of advanced solid tumors.
Phase I ADC Therapeutics Antibody-Drug Conjugates (ADCs) Cancer This is an antibody-drug conjugate developed by ADC Therapeutics in early clinical development for the intravenous treatment of neuroendocrine tumors and carcinomas.
Phase I ADC Therapeutics Humanized Monoclonal Antibodies Cancer It is an afucosylated humanized antibody targeting cell surface antigen DLK-1, in early clinical development at Chiome Bioscience for the treatment of solid tumors.

If you are seeking more information about our anti-DLK1 recombinant antibody products, please don't hesitate to contact us. Our team is ready to provide you with all the details you need to make informed decisions. We are eager to establish a mutually beneficial partnership that enhances your research initiatives and contributes to the advancement of your scientific endeavors.

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