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FBL
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Protein class
Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, FBL, NOP5 and NOP56, plus a guide RNA (PubMed:1714385, PubMed:32017898). It is associated with the U3, U8, U13, X and Y small nuclear RNAs (PubMed:1714385). Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20 (PubMed:14583623, PubMed:17498821). Interacts with DDX5 and C1QBP (PubMed:10837141, PubMed:21536856). Interacts with NOL11 (PubMed:22916032). Interacts with PIH1D1 (PubMed:17636026). Interacts with RRP1B (PubMed:20926688). Interacts with NOLC1 (By similarity).
Molecular function
Methyltransferase, Ribonucleoprotein, RNA-binding, Transferase
More Types Infomation
- APC-A1/Human FBL (VSDIVGPDGLVY) MHC Tetramer (MHC-LC3406)
-
- Class: Class I
- Antigen: FBL
- Antigen Species: Human
- Peptide: VSDIVGPDGLVY
- Conjugate: APC
- PE-A1/Human FBL (VSDIVGPDGLVY) MHC Tetramer (MHC-LC3375)
-
- Class: Class I
- Antigen: FBL
- Antigen Species: Human
- Peptide: VSDIVGPDGLVY
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.