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FCER1G
Anti-FCER1G Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors.
Protein class
FDA approved drug targets
Predicted location
Membrane
Single cell type specificity
Group enriched (Hofbauer cells, Macrophages, Kupffer cells, Langerhans cells, NK-cells, monocytes, dendritic cells, granulocytes)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, plasmacytoid DC, classical monocyte, myeloid DC, basophil, neutrophil, NK-cell)
Cell line specificity
Group enriched (HEL, HMC-1, THP-1, U-266/84, U-937)
Interaction
IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide-linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (PubMed:8611682). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (PubMed:28652325) (By similarity). Associated with CLEC6A (By similarity). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with TARM1 (PubMed:26311901).
Molecular function
IgE-binding protein, Receptor
More Types Infomation
Related Diseases
Asthma