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FGG

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For Research Use Only. Not For Clinical Use.


Background

When a blood vessel is injured, and the blood is in contact with the injured vascular wall or the subcutaneous tissue in the blood vessel or the tissue factor flows into the blood, the blood coagulation reaction is started in which fibrinogen in the blood is converted to insoluble fibrin, and a net of the fibrin functions as a strong haemostatic plug and hardens the wound.
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Hepatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (Hep G2)

Interaction

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

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