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GCLC
Anti-GCLC Recombinant Antibody Products
- Mouse Anti-NHP GCLC Recombinant Antibody (clone OTI1A3) (VS-1024-XY217)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF
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For Research Use Only. Not For Clinical Use.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Urothelial cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (A549, Hep G2, OE19, RT4)
Interaction
Heterodimer of a catalytic heavy chain and a regulatory light chain.
Molecular function
Ligase
More Types Infomation