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HSD17B1

17β-HSD1, a member of 17β-HSDs, catalyzes the conversion of the ketone group to the alcohol group at the C17 position of estrone and converts the low biologically active estrone into highly bioactive estradiol, which is a catalytic reduction. The enzyme of the reaction. This enzyme is a key enzyme in the final step of estradiol synthesis and is an important enzyme that directly regulates the pre-receptor level of diols in local tissues. 17β-HSD1 plays a very important role in the conversion of estrogen. The substrates catalyzed by it include estradiol (E2), estrone, dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and male. Androstenedione (4 dione) and the like. 17β-HSD1 catalyzes the highest efficiency of estrone activation. The promoter of the 17β-HSD1 gene contains a typical GC-rich region, so the expression of 17β-HSD1 may be increased in estrogen receptor-positive cells. 17β-HSD1 is mainly distributed in ovarian tissue, placental tissue and breast tissue, and its expression rate is significantly increased in 60% of malignant tissues, and it is directly related to apoptosis. Foreign scholars in the study of breast cancer cells MCF-7 and T47D confirmed that after inhibition of 17β-HSD1 expression by siRNA, activated estrogen was significantly reduced, cell proliferation decreased, indicating that 17β-HSD1, involved in estrogen-dependent diseases happened. Other studies have found that progesterone can increase 17β-HSD1 activity and promote mRNA expression.
Sex steroids are very important in the process of gonad differentiation in fish. 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1) is one of the key enzymes in the sex hormone synthesis pathway, and its main role in many species is to convert estrone (E) to estradiol (E2). 17B-HSD1 is more intensive in human studies, and its expression in ovarian or placenta-producing steroid-producing tissues is up-regulated in breast cancer patients, resulting in excessive E2 production, which in turn stimulates cell proliferation in tumors. 17B-HSD1 has been reported in fish research. For example, 17β-HSD1 of carp (Clarias batrachus) is mainly expressed in the ovary; some fish also have reports on its synthesis of androgen synthesis, such as in Nile tilapia (Oreochromis) Androstenedione can be converted to testosterone (T) in niloticus, albeit inefficiently. Thus, 17β-HSD1 is involved in the synthesis of E2 and T and plays a very important role in gonadal differentiation and gametogenesis in teleost fish. 17β-HSD1 is also expressed and functions in tissues other than the gonads, such as a small amount of expression in the tissues of the zebrafish (Danio rerio) such as skin, muscle and eyes.
HSD17B1
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Granulosa cells, Syncytiotrophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enriched (BEWO)

Interaction

Homodimer. Exists predominantly as an homodimer but also exits as monomer.

Molecular function

Oxidoreductase

More Types Infomation

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