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Histone H4K5ac/K8ac
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For Research Use Only. Not For Clinical Use.
Background
MLL (myeloid/lymphoid or mixed-lineage leukemia), also known as Histone-lysine N-methyltransferase HRX, is a crucial enzyme that contains a SET-domain. It functions as a histone methyltransferase, specifically adding methyl groups to lysine 4 of histone H3 (H3K4). Through this activity, MLL serves as a potent transcriptional activator for a wide range of target genes, notably including several HOX genes, which are critical for development.