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IL12RB1
Anti-IL12RB1 Recombinant Antibody Products
- AbPlus™ Anti-IL12RB1 Magnetic Beads (VS-0724-YC1416) (VS-0724-YC1416)
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- Target: IL12RB1
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
IL12RB1 encodes the beta subunit of the IL-12 receptor, which is involved in the immune response against infections. IL-12 is a cytokine that promotes the differentiation of T-helper cells into Th1 cells, which are important for fighting intracellular pathogens like viruses and certain bacteria. IL12RB1 deficiency impairs this immune pathway, leading to increased susceptibility to infections such as mycobacterial diseases. This gene is vital for the development of adaptive immune responses, particularly for combating chronic infections.
Protein class
CD markers, Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (NK-cells, dendritic cells, T-cells, Plasma cells, Kupffer cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-698)
Interaction
Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor.
Molecular function
Receptor
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