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IL1RL2

Anti-IL1RL2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with
transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1
alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family
genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin
1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene
cluster in a region mapped to chromosome 2q12.
Protein class

Enzymes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Excitatory neurons, Glandular and luminal cells, Langerhans cells, Basal keratinocytes, Suprabasal keratinocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A-431, ASC TERT1, HaCaT, HSkMC, hTCEpi)

Interaction

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).

Molecular function

Hydrolase, Receptor

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