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IL23R

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Early spermatids, Late spermatids, T-cells, Enteroendocrine cells)

Immune cell specificity

Immune cell enriched (MAIT T-cell)

Cell line specificity

Cell line enhanced (HL-60, HMC-1, K-562, U-2197)

Interaction

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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