IRS1

Tetramer Products Recombinant Antibody Products Functional Antibody Products Formats

Anti-IRS1 Recombinant Antibody Products

Mouse Anti-NHP IRS1 Recombinant Antibody (VS-1024-XY286) (VS-1024-XY286)
- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (DS1861AB) (MOR-1861)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (TH148DS) (MOR-4635)
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P
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Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (TH203DS) (MOR-4689)
- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, ICC, FC
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Rabbit Anti-IRS1 Recombinant Antibody (clone AFY0016) (MOR-0045-FY)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC, WB, Inhib
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For Research Use Only. Not For Clinical Use.

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Protein class

Disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Theca cells, Granulosa cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Low cell line specificity

Interaction

Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (PubMed:16127460). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (PubMed:7541045, PubMed:7559478, PubMed:7537849). Interacts with ALK (PubMed:15226403, PubMed:16878150). Interacts with EIF2AK2/PKR (By similarity). Interacts with GKAP1 (By similarity). Interacts with DGKZ in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with DGKZ and PIP5K1A in the absence of insulin stimulation (By similarity).

Molecular function

Transducer

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Related Signaling Pathways

Insulin Signaling Pathway