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Integrin αIIbβ3
Antibody-like Scaffold Protein Products
Recombinant Antibody Products
Functional Antibody Products
Formats
Anti-Integrin αIIbβ3 Recombinant Antibody Products
- Anti-Human Integrin αIIbβ3 Recombinant Antibody (TAB-447CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
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- Anti-human Integrin αIIbβ3 scFv Fragment (RAD87) (TAB-754LC-S(P))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 Fab Fragment (RAD87) (TAB-754LC-F(E))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 Fab Fragment (Humanized C4G1 ) (TAB-747LC-F(E))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 scFv Fragment (Humanized C4G1 ) (TAB-747LC-S(P))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 Fab Fragment (Chimeric C4G1) (TAB-746LC-F(E))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 scFv Fragment (Chimeric C4G1) (TAB-746LC-S(P))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-human Integrin αIIbβ3 scFv Fragment (c3C7) (TAB-753LC-S(P))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Anti-human Integrin αIIbβ3 Fab Fragment (c3C7) (TAB-753LC-F(E))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban.
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen
The integrin αIIbβ3 specific antibodies are used for treatment to prevent thrombosis in conditions selected from the group consisting of pulmonary embolism, transient ischemic attacks (TIAs), deep vein thrombosis, coronary bypass surgery, and surgery to insert a prosthetic valve or vessel in autologous, non-autologous, or synthetic vessel graft. A further embodiment contemplates using the antibody that specifically immunoreacts with integrin αIIBβ3 as a medicament for treatment to prevent thrombosis.