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KCNJ5
Loading...Anti-KCNJ5 Products
- Rabbit Anti-KCNJ5 Polyclonal Antibody (MRO-1996-CN) (MRO-1996-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (HBEC3-KT)
Interaction
May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
Molecular function
Ion channel, Voltage-gated channel
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