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KCNK9
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Group enriched (Excitatory neurons, Late spermatids, Inhibitory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homodimer (Probable). Heterodimer with KCNK1.
Molecular function
Ion channel, Potassium channel
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