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KDM6A
Anti-KDM6A Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IHC
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- Mouse Anti-KDM6A Recombinant Antibody (clone 5C2A9) (VS7-0425-WR205)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC
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- Mouse Anti-KDM6A Recombinant Antibody (clone 6E2D6) (VS7-0425-WR206)
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- Species Reactivity: Human, Rat
- Type: Mouse IgG2a
- Application: WB
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For Research Use Only. Not For Clinical Use.
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with TLE1 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:17500065, PubMed:17713478). Interacts with SUPT6H. Interacts with SMARCA4 (By similarity).
Molecular function
Chromatin regulator, Dioxygenase, Oxidoreductase
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