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KLF4
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Anti-KLF4 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Protein class
Cancer-related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Basal squamous epithelial cells, Distal enterocytes, Intestinal goblet cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (ASC TERT1, hTCEpi, hTERT-HME1, OE19, U-2197)
Interaction
Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain) (PubMed:17308127). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a (PubMed:21746878). Interacts with ZNF296 (By similarity). Interacts with GLIS1 (PubMed:21654807). Interacts with BTRC; this interaction leads to KLF4 ubiquitination and subsequent degradation (By similarity).
Molecular function
Activator, DNA-binding
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