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KRT5
Anti-KRT5 Recombinant Antibody Products
- AbPlus™ Anti-KRT5 Magnetic Beads (VS-0724-YC1518) (VS-0724-YC1518)
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- Target: KRT5
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Basal squamous epithelial cells, Basal prostatic cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Group enriched (HaCaT, HBEC3-KT, hTCEpi)
Interaction
Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network (PubMed:28899683). Heterodimer with KRT14 (PubMed:22705788). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity).
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