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LCN2
Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
Protein class
Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Urothelial cells, Ductal cells, Club cells, Pancreatic endocrine cells, Basal respiratory cells, Respiratory ciliated cells)
Immune cell specificity
Group enriched (neutrophil, basophil, non-classical monocyte)
Cell line specificity
Group enriched (CAPAN-2, EFO-21)
Interaction
Monomer (PubMed:7683678, 1281792). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678).
More Types Infomation
- Recombinant Human Anti-human LCN2 Antibody scFv Fragment (MHH-614-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Human Anti-human LCN2 Antibody Fab Fragment (MHH-614-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IHC, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, FACS, FuncS
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- Derivation: Rat
- Species Reactivity: Mouse
- Type: Rat scFv
- Application: WB
-
- Derivation: Rat
- Species Reactivity: Mouse
- Type: Rat Fab
- Application: WB
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- Derivation: Rat
- Species Reactivity: Mouse
- Type: Rat IgG
- Application: WB
- Recombinant Mouse Anti-Rat LCN2 Antibody (clone 8) (MOB-1247MZ)
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- Species Reactivity: Rat
- Type: Mouse antibody
- Application: ELISA, WB
- Recombinant Anti-human LCN2 Antibody scFv Fragment (MOB-614-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Recombinant Anti-human LCN2 Antibody Fab Fragment (MOB-614-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, FACS, FuncS
- Recombinant Anti-human LCN2 Antibody (MOB-614)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IF, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-LCN2 Recombinant Antibody (clone CB54YJ) (MOB-005YJL)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P, ELISA, IHC-Fr, WB
- Rat Anti-Lcn2 Recombinant Antibody (clone CB119L) (MOB-033YJL)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: WB, Neut
- Rat Anti-LCN2 Antibody (clone mAb 1857), mRNA (PABL-651-mRNA)
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- Species Reactivity: Mouse
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: N/A
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: N/A
- Anti-Human LCN2 Recombinant Antibody Fab Fragment (1-903-430) (TAB-487MZ-F(E))
-
- Application: ELISA
- Anti-Human LCN2 Recombinant Antibody Fab Fragment (1-2322-455) (TAB-486MZ-F(E))
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- Application: ELISA
- Anti-Human LCN2 Recombinant Antibody scFv Fragment (1-903-430) (TAB-487MZ-S(P))
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- Application: ELISA
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For Research Use Only. Not For Clinical Use.