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LCN2

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For Research Use Only. Not For Clinical Use.


Background

LCN2 (Lipocalin 2) is a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. Lipocalin-2 is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. Diseases associated with LCN2 include Klebsiella Infection and Kidney Disease.
LCN2
Protein class

Candidate cardiovascular disease genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Urothelial cells, Ductal cells, Club cells, Pancreatic endocrine cells, Basal respiratory cells, Respiratory ciliated cells)

Immune cell specificity

Group enriched (neutrophil, basophil, non-classical monocyte)

Cell line specificity

Group enriched (CAPAN-2, EFO-21)

Interaction

Monomer (PubMed:7683678, 1281792). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678).

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