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MCHR1
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
Protein class
G-protein coupled receptors, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Melanocytes, Inhibitory neurons, Excitatory neurons, Microglial cells, Leydig cells, Hepatic stellate cells, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (NTERA-2, RH-30, SuSa, T-47d, U-87 MG)
Interaction
Interacts with NCDN.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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