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MLH1
Loading...Anti-MLH1 Products
- Mouse Anti-MLH1 Recombinant Antibody (MOB-0124F) (MOB-0124F)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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- Mouse Anti-NHP MLH1 Recombinant Antibody (clone 4C9C7) (VS-1024-XY324)
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- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG1
- Application: WB, IHC, ICC, ELISA
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P, IP, FC
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- Mouse Anti-MLH1 Monoclonal Antibody (VS7-0425-WR391) (VS7-0425-WR391)
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- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ICC, ELISA
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- Anti-MLH1 Immunohistochemistry Kit (VS-0525-XY4417)
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- Species Reactivity: Human
- Target: MLH1
- Application: IHC
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- Anti-Rat MLH1 Immunohistochemistry Kit (VS-0525-XY4418)
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- Species Reactivity: Human, Rat
- Target: MLH1
- Application: IHC
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- Anti-Mouse MLH1 Immunohistochemistry Kit (VS-0525-XY4419)
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- Species Reactivity: Human, Mouse, Rat
- Target: MLH1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). Heterodimer of MLH1 and PMS2 (MutL alpha), MLH1 and PMS1 (MutL beta) or MLH1 and MLH3 (MutL gamma). Forms a ternary complex with MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3). Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex (PubMed:10783165). This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains (PubMed:10097147). Interacts with MCM9; the interaction recruits MLH1 to chromatin (PubMed:26300262). Interacts MCM8 (PubMed:26300262). Interacts with PMS2 (PubMed:11427529, PubMed:22753075). Interacts with MBD4 (PubMed:10097147). Interacts with EXO1 (PubMed:11427529, PubMed:11429708, PubMed:12414623, PubMed:14676842, PubMed:22753075). Interacts with MTMR15/FAN1 (PubMed:20603073).
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