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NANOG
Cancer Stem Cell Biomarker Specific Antibody Products
AbPlus
Recombinant Antibody Products
Formats
Research Area
Anti-NANOG Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Spermatocytes)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enriched (NTERA-2)
Interaction
Interacts with SMAD1 (By similarity). Interacts with SALL4 (By similarity). Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; reciprocally modulates their transcriptional activities (By similarity). Interacts with NSD2 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding, Repressor
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