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NOD2
Anti-NOD2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.
Related Signaling Pathways
NLR Signaling Pathway
TNF Signaling Pathway