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NOS3
Anti-NOS3 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IHC, IP
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- Rabbit Anti-NOS3 Polyclonal Antibody (MRO-1840-CN) (MRO-1840-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IHC
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- Mouse Anti-NOS3 Antibody (clone Mix) (ZG-0013C)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
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- Mouse Anti-NOS3 Recombinant Antibody (VS3-CJ858) (VS3-CJ858)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC
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- Mouse Anti-NOS3 Recombinant Antibody (clone 6H2) (VS3-XY1172)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC
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- Mouse Anti-NOS3 Antibody (clone Mix-mA) (VS3-WK1419)
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: WB
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- Recombinant Mouse Anti-NOS3 Antibody (VS3-FY500) (VS3-FY500)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Endothelial cells, Late spermatids, Hepatic stellate cells, Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BEWO, HUVEC TERT2, K-562, TIME)
Interaction
Homodimer. Interacts with NOSIP and NOSTRIN (PubMed:11149895, PubMed:12446846). Interacts with HSP90AB1 (PubMed:23585225, PubMed:11149895, PubMed:12446846) (By similarity). Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
Molecular function
Calmodulin-binding, Oxidoreductase
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