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Anti-NOV Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
Protein class
Plasma proteins, Transporters
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Adipocytes, Fibroblasts, Smooth muscle cells, Endothelial cells)
Immune cell specificity
Group enriched (eosinophil, neutrophil)
Cell line specificity
Cell line enhanced (BJ hTERT+, hTERT-RPE1, U-2197)
Interaction
Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region) (PubMed:12050162). Interacts with GJA1/CX43 (PubMed:15181016, PubMed:15213231). Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:12695522, PubMed:15611078). Interacts with ZDHHC22; the interaction may lead to CCN3 palmitoylation (By similarity).
Molecular function
Growth factor
More Types Infomation