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NRG1
Anti-NRG1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Immune cell enriched (classical monocyte)
Cell line specificity
Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
Interaction
The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).
Molecular function
Growth factor
More Types Infomation
Related Signaling Pathways
ErbB Signaling Pathway