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PAX2
Anti-PAX2 Recombinant Antibody Products
- AbPlus™ Anti-PAX2 Magnetic Beads (VS-0724-YC344) (VS-0724-YC344)
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- Target: PAX2
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Collecting duct cells, Endometrial ciliated cells, Distal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AN3-CA, EFO-21, RPTEC TERT1)
Interaction
Interacts with ELGN3; the interaction targets PAX2 for destruction. Interacts with TLE4.
Molecular function
Developmental protein, DNA-binding
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