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PDGFB
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Pancreatic endocrine cells, Langerhans cells, Macrophages)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enhanced (A-431, EFO-21, HUVEC TERT2, SK-BR-3, TIME)
Interaction
Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with LRP1 (PubMed:15053742). Interacts with SORL1 (via the N-terminal ectodomain) (PubMed:15053742, PubMed:16393139).
Molecular function
Developmental protein, Growth factor, Mitogen
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP, IF, ELISA
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FuncS
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human, Predicted to work with: Sheep
- Type: IgG
- Application: WB, IHC-P
- Human Anti-PDGFB Recombinant Antibody (clone AB-001) (FAMAB-0652WJ)
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
- Rat Anti-PDGFB Recombinant Antibody; scFv Fragment (HPAB-0386-CN-S(P)) (HPAB-0386-CN-S(P))
-
- Species Reactivity: Human, Rat
- Type: Rat scFv
- Application: ELISA, Block
- Human Anti-PDGFB Recombinant Antibody; scFv Fragment (HPAB-0385-CN-S(P)) (HPAB-0385-CN-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, IF, Block
- Human Anti-PDGFB Recombinant Antibody (HPAB-0390-CN) (HPAB-0390-CN)
-
- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized IgG
- Application: ELISA, Block
- Human Anti-PDGFB Recombinant Antibody (HPAB-0389-CN) (HPAB-0389-CN)
-
- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized IgG
- Application: ELISA, Block
- Rat Anti-PDGFB Recombinant Antibody (HPAB-0388-CN) (HPAB-0388-CN)
-
- Species Reactivity: Human, Rat
- Type: Rat IgG2b, κ
- Application: ELISA, Block
- Rat Anti-PDGFB Recombinant Antibody (HPAB-0387-CN) (HPAB-0387-CN)
-
- Species Reactivity: Human, Rat
- Type: Rat IgG2b, λ
- Application: ELISA, Block
- Rat Anti-PDGFB Recombinant Antibody (HPAB-0386-CN) (HPAB-0386-CN)
-
- Species Reactivity: Human, Rat
- Type: Rat IgG2b, κ
- Application: ELISA, Block
- Human Anti-PDGFB Recombinant Antibody (HPAB-0385-CN) (HPAB-0385-CN)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, IF, Block
- Anti-Human PDGFB Recombinant Antibody scFv Fragment (C12) (TAB-1021CL-S(P))
-
- Derivation: Humanized F3 display library
- Type: Humanized antibody
- Application: ELISA
- Anti-Human PDGFB Recombinant Antibody scFv Fragment (F3) (TAB-1020CL-S(P))
-
- Type: Rabbit mAb
- Application: ELISA
- Anti-Human PDGFB Recombinant Antibody Fab Fragment (C12) (TAB-1021CL-F(E))
-
- Derivation: Humanized F3 display library
- Type: Humanized antibody
- Application: ELISA
- Anti-Human PDGFB Recombinant Antibody Fab Fragment (F3) (TAB-1020CL-F(E))
-
- Type: Rabbit mAb
- Application: ELISA
- Becaplermin (TP-061CL)
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- CAS number: 165101-51-9
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