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PDPN
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Anti-PDPN Recombinant Antibody Products
- Recombinant Human Podoplanin Fc Chimera Protein (CBP-157YJL)
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- Species Reactivity: Human
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- Recombinant Human Podoplanin Protein (CBP-215YJL)
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- Application: Positive Control, Immunogen, SDS-PAGE, WB, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Fibroblasts, monocytes, Alveolar cells type 1, Basal respiratory cells, Muller glia cells, Peritubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, EFO-21, HAP1, HHSteC, NTERA-2, SuSa, TIME)
Interaction
Homodimer (PubMed:21376833). Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans (PubMed:18215137, PubMed:17616532, PubMed:25458834). Interacts with CD9; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN (PubMed:18541721). Interacts with LGALS8; the interaction is glycosylation-dependent; may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). Interacts with HSPA9 (PubMed:23541579). Interacts (via extracellular domain) with CD44; this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267). Interacts (via cytoplasmic domain) with MSN and EZR; activates RHOA and promotes epithelial-mesenchymal transition (PubMed:17046996). Interacts with CCL21; relocalized PDPN to the basolateral membrane (PubMed:14978162).
Molecular function
Developmental protein
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