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PECAM1
Anti-PECAM1 Recombinant Antibody Products
- Recombinant Mouse Anti-PECAM1 Antibody (HEC7) (NEUT-1852CQ)
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- Species Reactivity: Human, Rat, Bovine
- Type: IgG2a
- Application: BL, ELISA, FC, ICC/IF, IHC, IP, WB
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- Mouse Recombinant Hamster Anti-PECAM1 Antibody (NEUT-1853CQ)
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- Species Reactivity: Mouse
- Type: IgG
- Application: FC, FuncS
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- Recombinant Armenian Hamster Anti-PECAM1 Antibody (2H8) (NEUT-1854CQ)
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- Species Reactivity: Mouse, Hamster, Human
- Type: IgG
- Application: ELISA, IP, IHC, ICC, Neut, FC
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- Recombinant Mouse Anti-PECAM1 Antibody (WM59) (NEUT-1855CQ)
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- Species Reactivity: Human, African Green, Baboon, Cynomolgus, Rhesus
- Type: IgG1, κ
- Application: FC, IHC, IF, BL
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- Recombinant Rat Anti-Pecam1 Antibody (390) (NEUT-1856CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, IP, IHC-Fr, ICC, BL
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For Research Use Only. Not For Clinical Use.
PECAM1 (Platelet Endothelial Cell Adhesion Molecule 1) is a glycoprotein expressed on the surface of endothelial cells, platelets, and leukocytes. It plays a vital role in immune cell migration, angiogenesis, and the maintenance of the blood-brain barrier. PECAM1 is involved in the regulation of inflammation, atherosclerosis, and tissue repair, and it is often studied in the context of cardiovascular and autoimmune diseases.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Macrophages)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Group enriched (HUVEC TERT2, TIME)
Interaction
Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302). Forms a complex with BDKRB2 and GNAQ (PubMed:18672896). Interacts with BDKRB2 and GNAQ (PubMed:18672896). Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684). Interacts with FER (By similarity). Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308).
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