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PECAM1
Anti-PECAM1 Recombinant Antibody Products
- Mouse Anti-NHP PECAM1 Recombinant Antibody (clone WM59) (VS-1024-XY90)
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- Species Reactivity: Cynomolgus monkey, Human, Mouse, Non-human primate, Rhesus monkey
- Type: Mouse IgG1
- Application: IF, FC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Macrophages)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Group enriched (HUVEC TERT2, TIME)
Interaction
Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302). Forms a complex with BDKRB2 and GNAQ (PubMed:18672896). Interacts with BDKRB2 and GNAQ (PubMed:18672896). Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684). Interacts with FER (By similarity). Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308).
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