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PLCB1

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Astrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (CACO-2, Hep G2)

Interaction

Interacts with DGKQ.

Molecular function

Hydrolase, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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