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PRLR
Anti-PRLR Recombinant Antibody Products
- Anti-PRLR-SMCC-DM1 ADC (ADC-074CL)
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- Target: prolactin receptor (PRLR)
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: maytansinoid DM1 (maytansinoid N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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For Research Use Only. Not For Clinical Use.
Enables prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including activation of protein kinase activity; cytokine-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor).
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Endometrial stromal cells, Granulosa cells, Breast glandular cells, Proximal tubular cells, Syncytiotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (T-47d)
Interaction
Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
Molecular function
Receptor
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