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PTCRA
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.
Predicted location
Membrane
Single cell type specificity
Group enriched (Macrophages, dendritic cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Group enriched (MOLT-4, SK-MEL-30)
Interaction
Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1.
Molecular function
Receptor
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