Anti-PVRIG Recombinant Antibody Products

Creative Biolabs offers a large range of precisely produced anti-PVRIG recombinant antibodies. These antibodies are tuned for best research performance. For researchers and pharmaceutical companies creating targeted cancer immunotherapies, their remarkable target specificity, structural stability, and functional potency can be absolutely essential tools.

PVRIG: A Compelling Target for Cancer Therapy

Recently identified immunological checkpoint molecule poliovirus receptor-related immunoglobulin domain-containing (PVRIG) offers a potential path for cancer treatment. Expressed on cytotoxic lymphocytes such as NK cells, this inhibitory receptor binds to its single ligand, poliovirus receptor-related 2 (PVRL2 or CD112), therefore reducing their activity by an ITIM-like pattern. Especially, suppressing PVRIG has shown the capacity to greatly increase NK cell-mediated killing of AML cell lines expressing PVRL2 and to increase NK cell activation against main AML patient samples, so emphasising PVRIG as a fascinating target for immunotherapeutic intervention in malignancy.

Alternative Names

Poliovirus receptor-related immunoglobulin domain-containing; CD112R; C7orf15; PVR related immunoglobulin domain containing.

Background

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Anti-PVRIG rAb Products

Creative Biolabs specializes in providing high-quality anti-PVRIG recombinant antibodies. For many different experimental needs, our multi-stage quality assurance system ensures dependable biological activity and batch-to- batch repeatability by combining strict production controls with modern analytical characterization. We guarantee antibodies with extraordinary target specificity, nanomolar-range affinity metrics, and strong performance consistency in many technical implementations from flow cytometry to in vivo models by means of methodical validation processes covering functional assays and cross-reactivity profiling.

Table 1. Featured anti-PVRIG recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs offers premium anti-PVRIG recombinant antibodies supported by a strict quality assurance system. For many different experimental uses, our methods combine strict process controls with cutting-edge analytical techniques to provide constant biological activity and dependable batch-to-batch repeatability. From flow cytometry to complicated in vivo research, every antibody undergoes methodologically consistent validation, including functional testing and cross-reactivity tests, guaranteeing extraordinary target selectivity, nanomolar affinity levels, and stable performance across approaches.

Customer Reviews

Excellent

Va***e
Human Anti-PVRIG Recombinant Antibody (HPAB-0781LY) (HPAB-0781LY)

We've been using this anti-PVRIG antibody for our in-house ELISA to quantify soluble PVRIG protein levels in patient samples for the past six months, and it has consistently delivered excellent results. The antibody exhibits high sensitivity, allowing us to detect even low concentrations of the target protein. We've observed minimal background noise, leading to clear and easily quantifiable signals. Batch-to-batch consistency has also been impressive, which is crucial for longitudinal studies. The provided datasheet was comprehensive, offering clear guidelines for optimal dilution and blocking conditions. Overall, this is a highly reliable and robust antibody for PVRIG detection via ELISA and has become an indispensable tool in our research.

3/Dec/2023

Excellent

Ol***n
Human Anti-PVRIG Recombinant Antibody (HPAB-0783LY) (HPAB-0783LY)

We purchased this anti-PVRIG antibody for flow cytometric analysis to assess PVRIG expression on various immune cell populations, particularly NK cells and T cells. The antibody demonstrated excellent specificity, showing distinct staining on cells known to express PVRIG with minimal off-target binding to control populations. The staining intensity was strong and provided a good separation between positive and negative cells, making gating straightforward.

11/Aug/2024

Excellent

Sh***a
Human Anti-PVRIG Recombinant Antibody (HPAB-0786LY) (HPAB-0786LY)

Our lab has been investigating the functional consequences of PVRIG blockade on NK cell cytotoxicity against tumor cells. This anti-PVRIG antibody has proven to be highly effective in blocking the PVRIG-PVRL2 interaction in our in vitro assays. We observed a significant enhancement of NK cell-mediated killing of PVRL2-expressing target cells upon pre-incubation with this antibody. Titration experiments showed a clear dose-dependent blocking effect. The antibody is well-tolerated by the cells in culture and doesn't exhibit any significant non-specific effects.

9/Oct/2024

rAb Production

By utilizing state-of-the-art recombinant antibody engineering, Creative Biolabs delivers standardized batches of anti-PVRIG recombinant antibodies through validated manufacturing workflows, ensuring continuous availability for global biomedical research applications.

Featured Anti-PVRIG Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PVRIG recombinant antibody production.

Fig.2 Gram-scale anti-PVRIG recombinant antibody production.

rAb Modalities

Creative Biolabs offers tailored solutions for anti-PVRIG research with a comprehensive selection of high-quality recombinant antibodies available in various formats, precisely engineered to meet the unique requirements of researchers worldwide.

Fig.3 Full-length anti-PVRIG recombinant antibody production and modalities.

PVRIG-Targeted Drug Information

Table 2. Public drug targeting PVRIG.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

For additional information regarding our anti-PVRIG recombinant antibody products or to make an inquiry, please feel free to reach out to us at your convenience.